The Japanese publisher has talked about whether the events of the Nintendo Wii game are really part of the franchise’s timeline, or if it’s just a fiction that’s part of the game and has no impact on anything else…
Since its inception in 1996, there have been quite a few Resident Evil games released. Main episodes, spin-offs (Gun Survivor…), multiplayer projects, you could list them all at length, mentioning the target platforms and the year of release. There are two rail-shooters (i.e. your character moves on its own, but you have to aim and shoot), Resident Evil: The Umbrella Chronicles and Resident Evil: The Darkside Chronicles, both of which retell the events of Resident Evil, and there has been some debate about whether or not they are canon, i.e. whether or not they are officially part of the franchise.
In the Resident Evil 4 Remake, there was a reference to the military operation Operation Javier in The Darkside Chronicles. Because of this, IGN interviewed Yoshiaki Hirabayashi, the producer of Resident Evil 4 Remake. He replied that Operation Javier did happen, so it is indeed part of the main story of Resident Evil, but what that mission was is not exactly the same as it was portrayed in Resident Evil: The Darkside Chronicles. So the answer is yes, but how and what happened during the mission may be different, and it follows that Resident Evil: The Darkside Chronicles is officially tied to the main storyline of the franchise, only the events depicted there may be different from the events mentioned in the other games.
Resident Evil is never consistent in how characters are portrayed. A prime example of this is Chris Redfield, who has changed his appearance significantly over the past decade (even between Resident Evil 7: Biohazard and its sequel, Resident Evil: Village, we can see the change). This leads to the assumption that Capcom is also a bit lax when it comes to events, as there are a lot of changes.